Best Pitching Prop Bets for MLB 2025 Season

The start of the 2025 MLB regular season is already upon us. DraftKings, FanDuel, and other major sportsbooks have a catalogue of player props to get stuck into – we’ve covered the RBI markets and homers, now it’s time to take a look at the best pitching prop bets.

Any futures bet involving a pitcher carries a considerable amount of injury risk. Numerous Cy Young candidates missed a large portion or all of the 2024 season, and that pattern is already repeating in 2025.

Gerrit Cole is heading for Tommy John surgery, George Kirby is likely to miss opening day, and Grayson Rodriguez has inflammation in his right elbow, leaving an uncertain prognosis.

Sean Burke to have 120+ strikeouts — +100 at DraftKings

Sean Burke struck out 12 hitters per nine innings in Triple-A last season. He had 22 strikeouts in 19 MLB innings and enters the year as a member of the Chicago White Sox’s rotation.

Projections have Burke breaking the 110-inning threshold. Chicago has no reason to push him to uncomfortable levels workload-wise, but he threw 90 innings last season and over 100 in 2022.

His stuff was good across the board in his brief MLB stay last season. The 28.9% strikeout rate might not sustain over a full season, yet if he averages even a strikeout per inning, this is well within reach.

Garrett Crochet to have 250+ strikeouts — +430 at FanDuel

Garrett Crochet had 209 strikeouts in 146 innings in 2024. He averaged a shade over three innings per start after the All-Star break, as he looked to protect his arm amid a lost White Sox season.

Crochet is now the ace of a Boston Red Sox team with a real chance of winning the American League East. In an ultra-small spring sample, he has 14 strikeouts in 6.1 innings, with his stuff looking as sharp as ever.

His 113 stuff+ last season was the best of any pitcher to throw 100 or more innings. Only Corbin Burnes and Paul Skenes had a better pitching+.

Crochet is a legitimate Cy Young candidate, who only needs to throw 175 innings to reach 250 strikeouts if he maintains his rate from last season. There won’t be any workload management if the Red Sox are in a fight for a playoff spot.

Hunter Brown to have 170+ strikeouts — +100 at DraftKings

Hunter Brown had a 2.20 ERA over his final 19 starts of the 2024 regular season. Striking out 119 hitters in 114.2 frames, Brown got to 179 strikeouts in 170 innings for the season.

This followed 178 strikeouts in under 160 innings in 2023. His six-pitch arsenal has an excellent mix of good stuff and command, making him a dark-horse candidate for the AL Cy Young.

The volume – if he avoids injury – will be there. Brown probably doesn’t need to strikeout more than one hitter per inning to cash this bet, which seems like a great option after he’s gone over this number in each of the last two seasons.

Kodai Senga to have over 161.5 strikeouts — -104 at FanDuel

Kodai Senga struck out 202 hitters in 166.1 innings in 2023. After missing almost all of the 2024 season, it’s unlikely Senga pitches over 160 innings again, but he doesn’t need to throw more than 150 frames to hit this over.

Senga had nine strikeouts in 5.1 innings in his only appearance last season. There have been no hiccups in his return to action in spring, with a couple of strikeouts in two innings in his first appearance.

Adding a sinker to his repertoire, Senga should be looking at a strikeout rate in the high-20s once again. This over is well within reach if he makes 30+ starts.

Roki Sasaki to have under 143.5 strikeouts — -110 at FanDuel

Roki Sasaki struck out 11.4 per nine in Japan. Everything about Sasaki looks like an ace in the majors.

This wager isn’t about doubting Sasaki’s stuff or praying on an injury. It’s simply a question of volume. The Los Angeles Dodgers are going with a six-man rotation, which already limits the number of starts per pitcher.

Sasaki has only cleared this line once in his career (173 strikeouts in 2022). The Dodgers aren’t going to push him much beyond the 120-inning mark, and he might not even get that far.

Los Angeles is planning another deep postseason run. They will want Sasaki at his best in October, so there will be some skipped starts and brief IL stints to ensure he’s well-rested.

Logan Webb to have over 159.5 strikeouts — -113 at FanDuel

Logan Webb has cleared this line in three straight seasons. The San Francisco Giants ace was joint-18^th in pitching+ in 2024, having led the National League in innings for the second consecutive season.

This line seems harsh on Webb. Injuries are possible for any pitcher, but he’s been incredibly durable over the last few seasons.

While he doesn’t have electric stuff, he pitches enough innings to comfortably clear 160 strikeouts.

Raisel Iglesias to have 40+ saves — +190 at DraftKings

Only three pitchers have more saves than Raisel Iglesias since 2021. Despite celebrating his 35^th birthday in January, Iglesias has barely lost any velocity and has exceptional numbers across the board.

He’s a lock to close games for the Atlanta Braves, who are a candidate to win 95+ games with Spencer Strider and Ronald Acuña Jr. returning from injury.

Maintaining his command, getting plenty of chases, and coming off the best season of his career, Iglesias shows no signs of slowing down. This is great value.

Tarik Skubal to lead the majors in strikeouts — +950 at DraftKings

Seven pitchers have a better strikeout than Tarik Skubal since the start of 2023. Of those seven, at least four won’t have the volume to lead the majors in strikeouts.

Skubal just won the Triple Crown, striking out 228 hitters in 192 innings. This is a brilliant price for a pitcher coming off a season of that caliber, even with Paul Skenes as the clear favorite to be the strikeout champion.

Hunter Greene to have over 162.5 strikeouts — -113 at FanDuel

Hunter Greene hasn’t had the massive strikeout numbers that his high-velocity fastball might indicate on the surface. Greene has still struck out 29.6% of hitters in his MLB career, including 169 in 2024.

Projection systems are in agreement that the Cincinnati Reds right-hander will clear this line. Several have Greene getting up towards 200 strikeouts – he’s +235 for 200+ strikeouts at FanDuel.

With four great pitches, including an elite slider, Greene has the swing-and-miss to comfortably go past this number, even if he only throws 150 regular-season innings (as he did in 2024).

Alexis Díaz to have 30+ saves — +115 at DraftKings

The Reds won 77 games in 2024 and 82 in 2023. Alexis Díaz has been the team’s closer throughout the last two seasons, recording 37 saves in 2023 and 28 in 2024.

Cincy quietly has a chance to win the NL Central. Their lineup is deep. The rotation, led by Greene, could be in the top 10 in the big leagues. In a weak division, these Reds look set to be a .500 team at worst.

Díaz had 37 saves when Cincinnati won 82 games. He should easily break the 30 mark if the Reds are even on the fringes of the wild-card race.

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